
Southwestern-Style Meat Loaf Recipe
This Southwestern Meat Loaf takes the classic comfort dish and turns up the flavor with chili powder, cumin, peppers, corn, and a tangy salsa-style glaze. It’s hearty, colorful, and perfect when you want something familiar—but exciting.
Why You’ll Love This Recipe
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Bold Southwestern flavors
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Moist, tender texture
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Slight heat with customizable spice
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Perfect for tacos, sandwiches, or leftovers
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Easy pantry ingredients
Ingredients
Meat Loaf
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1½ lbs ground beef (or 50/50 beef & pork)
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1 cup milk
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1 cup breadcrumbs or crushed tortilla chips
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2 large eggs
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1 small onion, finely chopped
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1 red bell pepper, finely diced
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1 jalapeño, seeded & minced (optional)
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2 cloves garlic, minced
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1 cup corn kernels (fresh or frozen)
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½ cup shredded cheddar or pepper jack cheese
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⅓ cup salsa
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2 tbsp Worcestershire sauce
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1½ tsp chili powder
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1 tsp ground cumin
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½ tsp smoked paprika
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1 tsp salt
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½ tsp black pepper
Southwestern Glaze
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½ cup ketchup
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¼ cup salsa
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2 tbsp brown sugar
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1 tsp chili powder
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1 tbsp lime juice
Instructions
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Preheat oven to 350°F (175°C). Grease a loaf pan or line a baking sheet.
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In a large bowl, mix milk and breadcrumbs. Let soak 1 minute.
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Add eggs, onion, bell pepper, jalapeño, garlic, corn, cheese, salsa, Worcestershire sauce, and spices. Stir gently.
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Add ground meat and mix just until combined—do not overmix.
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Shape into a loaf or place in prepared pan.
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Stir glaze ingredients and spread half over the meat loaf.
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Bake for 45 minutes, remove from oven, spread remaining glaze on top.
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Return to oven and bake 15–20 minutes, until internal temperature reaches 160°F (71°C).
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Rest for 10 minutes, then slice and serve.
Pro Tips for Maximum Flavor
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Crushed tortilla chips add authentic texture
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Pepper jack cheese adds a mild kick
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Resting prevents crumbling
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For extra smokiness, add ½ tsp chipotle powder
Variations
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Tex-Mex Meat Loaf: Add black beans and taco seasoning
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Turkey Southwestern Meat Loaf: Use ground turkey + 1 tbsp olive oil
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Low-Carb: Skip breadcrumbs and use almond flour
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Extra Spicy: Add diced chipotle peppers in adobo
What to Serve with Southwestern Meat Loaf
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Mexican street corn
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Roasted sweet potatoes
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Black bean salad
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Avocado slices or guacamole
Storage & Leftovers
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Refrigerate: Up to 4 days
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Freeze: Up to 3 months
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Leftover ideas: Meatloaf tacos, burritos, or sandwiches
Final Thoughts
This Southwestern-Style Meat Loaf is the perfect fusion of comfort food and bold flavor. It’s hearty, colorful, and guaranteed to become a new household favorite.
* 1 pound ground beef, lean
* 3/4 to 1 pound ground veal
* 1 egg
* 1/2 cup fine dry bread crumbs
* 1 can (approx. 4 1/4 ounces) chopped ripe olives
* 1 can (4 ounces) chopped mild green chile pepper
* 1 cup corn kernels
* 1/2 cup salsa, plus more for topping
* 1 teaspoon onion powder
* 1/2 teaspoon garlic powder
* 1/8 teaspoon pepper
* 1/4 teaspoon salt, or to taste
Meatloaf Recipe Instructions:
Combine all ingredients except topping in a bowl and combine until blended.
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